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5 cards from this section. Quick, good the night before a test.
What is a genetic disease?
Think about where the instructions for proteins are stored.
What is a stem cell?
It has not yet chosen its job.
Which condition is caused by an extra copy of chromosome 21?
This one involves a whole chromosome rather than one gene.
Two carriers of cystic fibrosis have a child. What is the chance that the child has cystic fibrosis?
Draw the two-by-two Punnett square.
Huntington's disease is caused by a dominant allele (H). A father is heterozygous (Hh) and the mother is hh. (a) What is the probability that their first child inherits the disease allele? (b) If they have three children, what is the probability that none of them inherits it? (c) Huntington's symptoms usually begin in adulthood. Suggest one reason why some people at risk choose not to take a genetic test.
Multiply independent probabilities for (b).
Explain how the gene-edited treatment for sickle cell disease approved in 2023 combines stem cells and gene technology, and discuss two challenges that limit its use.
Describe the steps in order, then think about cost, access and side effects.
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