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3 cards from this section. Quick, good the night before a test.
What does ADME stand for?
Think about how a drug enters and exits the body.
Why are pre-clinical trials necessary?
Consider the implications of introducing a new drug to patients.
What are pre-clinical trials designed to evaluate?
Consider all the factors involved in ensuring a drug is ready for human trials.
True or False: Toxicology studies only focus on long-term effects of drugs.
Think about the different time frames involved in drug testing.
You have a drug candidate that shows promise in a pre-clinical model. However, during toxicology tests, it's observed to have a low therapeutic index. Discuss what implications this has for moving forward with clinical trials.
Consider how the safety profile influences the continuation of drug development.
In a series of pre-clinical trials, a drug candidate exhibited favorable pharmacokinetics but showed significant toxicity in acute studies. How might this affect the development process, and what steps could developers take next?
Reflect on how different outcomes in pre-clinical trials can lead to various paths in drug development.
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