Practice Hl: Structural Modifications And Drug Action (13.3.3) - Chapter 13: Option D – Medicinal Chemistry

Practice: HL: Structural Modifications and Drug Action

Lesson 13.3.3Option D – Medicinal Chemistry

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10 questions

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6 sample questions

Question 1.
What structural modification is made to morphine to create codeine?
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Think about how adding small groups might change the properties.
Question 2.
Which drug acts more quickly and is more addictive, morphine or heroin?
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Consider the lipophilicity of each drug.
3Question 3.
What structural change is made to morphine to create codeine?
- A) Methoxylation
- B) Methylation
- C) Esterification
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Focus on how small changes can affect potency.
4Question 4.
Which drug crosses the blood-brain barrier more rapidly?
- A) Morphine
- B) Codeine
- C) Heroin
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Think about the concept of lipophilicity in drug design.
Question 5.
Compare and contrast the mechanisms of action of morphine, codeine, and heroin, focusing on their structural differences.
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Focus on how each drug’s structure affects its potency and speed of action.
Question 6.
Propose a structural modification to heroin aimed at reducing its addictive potential without eliminating its analgesic properties.
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Consider how structural changes influence the drug's interaction with the central nervous system.

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